Modulation of cell calcium signals by mitochondria

It is now clearer and clearer that mitochondria play a role, and perhaps an active role, in cell calcium signalling. The fact that mitochondria can exhibit a Ca^2+>-induced Ca^2+> release (mCICR, Ichas et al. 37]) reinforces this concept and makes the mitochondria an essential element in the relay of Ca^2+> wave propagation. It must be emphasized that the modulation of cell Ca^2+> signals by mitochondria depends upon their energetic status, thus making mitochondria an essential link between energy metabolism and calcium signalling inside the cell.