Dicatonic 2,4-diaryl pyrimidines as DNA selective binding agents |
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| Authors: | Arvind Kumar Min Zhao W David Wilson and David W Boykin |
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| Institution: | Department of Chemistry, Georgia State University, Atlanta, Georgia 30303 USA |
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| Abstract: | A series of twelve 2,4-diaryl pyrimidines were synthesized. The interaction of these molecules with DNA was evaluated by study of their binding to their DNA duplex polymer poly dA·poly dT and the analogous RNA duplex polymer poly A·poly U which serves as a control for binding to non-specific nucleic acid sites. |
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