Natural resistance against hematopoietic cells in lethally-irradiated mice infected with Friend leukemia virus |
| |
| Authors: | A M Iorio M Neri P Enrico F Titti G B Rossi E Bonmassar |
| |
| Institution: | (1) Department of Virology, Institute of Hygiene, University of Perugia, Perugia, Italy;(2) Departments of Virology, Istituto Superiore di Sanita', and of Cellular and Developmental Biology, Faculty of Biological Sciences, University of Rome, Rome, Italy;(3) Department of Experimental Medicine and Biochemical Sciences, 2nd University of Rome, Rome, Italy |
| |
| Abstract: | Summary The influence of in vivo infection with the polycythemic substrain of Friend leukemia virus on noninducible ( natural ) resistance against allogeneic normal or malignant grafts was studied in lethally irradiated mice. Parallel studies were performed on the NK system in the same experimental conditions. The results indicate that FLV-P infection of mice with full (DBA/2) vs partial (BALB/c and CD2F1) susceptibility did not suppress their in vivo natural resistance against bone marrow or El-4 leukemia cells. On the other hand, a decline in NK activity paralleled the progression of leukemic disease in the more susceptible DBA/2 hosts.
Abbreviations used: FLV-P, N-tropic polycythemic substrain of Friend Leukemia Virus Complex; NR, natural resistance; NR in vivo, natural resistance against normal or malignant hemopoietic grafts occurring in vivo in lethally irradiated mice; NK, natural killer; (125I)IUdR, 125I-labeled 5-iodio-2 -deoxyuridine; IV, intravenous |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
