Elevated daytime rat pineal and serum melatonin levels induced by isoproterenol are depressed by swimming |
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| Authors: | W T Wu R J Reiter M E Troiani G M Vaughan |
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| Affiliation: | 1. Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7762, USA;1. Institute of Surgical Research, Brook Army Medical Center, Ft. Sam Houston, Texas 78234, USA;1. 1,rue Saint-Jean-Baptiste, 66650 Banyuls-sur-Mer, France;2. Faculté de médecine, 2, rue de l’École-de-Médecine, 34090 Montpellier, France;3. Alliance infirmière, 28, rue Saint-Sébastien, 66650 Banyuls-sur-Mer, France;1. School of Optical-Electrical and Computer Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;2. College of Communication and Art Design, University of Shanghai for Science and Technology, Shanghai 200093, China;3. Department of Printing and Packaging Engineering, Shanghai Publishing and Printing College, Shanghai 200093, China |
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| Abstract: | Isoproterenol (1 mg/kg) was subcutaneously injected into adult male rats during the day to stimulate pineal N-acetyltransferase (NAT) activity and pineal and serum melatonin levels. Two hours after isoproterenol administration when levels of each of these variables had increased significantly, the experimental animals swam for 10 min in 22 degrees C water. At 15 min after swimming onset, pineal and serum melatonin levels were highly significantly depressed compared to those in control animals that did not swim. The high NAT level was not influenced by swimming. In a second study, isoproterenol injected rats swam for either 1, 3, 6 or 10 min and were sampled 15 min after the onset of swimming. The reduction in the elevated pineal melatonin in these animals was correlated with the length of the swim, i.e., as the duration of swim increased the percent reduction in pineal melatonin also increased. Neither pineal NAT nor hydroxyindole-O-methyltransferase (HIOMT) activities were influenced by swimming. The results suggest that elevated pineal and serum melatonin induced by isoproterenol can be depressed with no effect on the activity of the enzymes which convert serotonin to melatonin. |
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