| RNA结合蛋白调节mRNA稳定性的作用机制 |
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| 引用本文： | 高媛,马大鹏.RNA结合蛋白调节mRNA稳定性的作用机制[J].微生物学免疫学进展,2012,40(2):79-83. |
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| 作者姓名： | 高媛 马大鹏 |
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| 作者单位： | 南华大学病原微生物研究所,衡阳,421001 |
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| 基金项目： | 国家自然科学基金课题，湖南省科技厅项目 |
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| 摘 要： | 免疫稳态的维持涉及多种细胞因子的基因表达调控,其中在转录后水平对mRNA稳定性的调控起重要作用。ARE(AU-rich element)位于mRNA 3'UTR(非编码区),富含AU碱基,某些RNA结合蛋白通过识别结合ARE影响mRNA的稳定性。本文综合最新研究,概述了TTP、HUR等RNA结合蛋白对mRNA稳定性的调节机制及其在信号通路中的作用。
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| 关 键 词： | ARE mRNA稳定性 RNA结合蛋白 信号通路 |
The mechanism of RNA binding protein regulating stability of mRNA |
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| GAO Yuan
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MA Da-peng.The mechanism of RNA binding protein regulating stability of mRNA[J].Progress In Microbiology and Immunology,2012,40(2):79-83. |
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| Authors: | GAO Yuan MA Da-peng |
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| Institution: | GAO Yuan,MA Da-peng,XIAO Jian-hua(＊ Institute of pathogens of University of South China,Hengyang 421001,China) |
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| Abstract: | The balance of immunity is related to induction of many cytokines and gene regulation,the regulation of mRNA stability is more important during this course.Some of RNA binding proteins regulate the stability of mRNA through binding to the AREs（AU-rich element） in the 3′UTR of mRNA.This review will mainly introduce the mechanism of TTP、HUR regulating mRNA stability and their role in immunity signaling pathway. |
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| Keywords: | ARE mRNA stability RNA biding protein Signaling pathway |
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