| 供浆者多次献浆后sdLDL-C和ox-LDL水平的测定 |
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| 引用本文： | 胡军,何彦林,刘学平,杨鸿雁,潘孟姣. 供浆者多次献浆后sdLDL-C和ox-LDL水平的测定[J]. 微生物学免疫学进展, 2012, 40(3): 43-46 |
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| 作者姓名： | 胡军 何彦林 刘学平 杨鸿雁 潘孟姣 |
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| 作者单位： | 兰州生物制品研究所有限责任公司,730046 |
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| 摘 要： | 目的探讨多次献浆后,对供浆者体内血浆小而密低密度脂蛋白胆固醇(sdLDL-C)、氧化低密度脂蛋白(ox-LDL)水平变化的影响。方法分别检测100例多次献血浆者和100例初次献血浆者的血浆sdLDL-C和ox-LDL水平,同时检测其血脂及血浆蛋白水平。结果多次献血浆者的血浆sdLDL-C、ox-LDL以及血脂水平略有下降,但与初次献浆者之间无显著性差异;多次献血浆者的血浆总蛋白(TP)、白蛋白(ALB)与初次献浆者的水平相当,两者之间也无显著性差异。结论多次献血浆是安全的,不会增加动脉粥样硬化性心血管疾病的风险。
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| 关 键 词： | 多次供浆者 小而密低密度脂蛋白(sdLDL-C) 氧化低密度脂蛋白(ox-LDL) 动脉粥样硬化 |
Measurement of levels of sdLDL-C and ox-LDL in plasma of donors for long-term intensive plasmapheresis |
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| HU Jun , HE Yan-lin , LIU Xue-ping , YANG Hong-yan , PAN Meng-jiao. Measurement of levels of sdLDL-C and ox-LDL in plasma of donors for long-term intensive plasmapheresis[J]. Progress In Microbiology and Immunology, 2012, 40(3): 43-46 |
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| Authors: | HU Jun HE Yan-lin LIU Xue-ping YANG Hong-yan PAN Meng-jiao |
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| Affiliation: | ( Lanzhou Institute of Biological Products Co. , Ltd. , Lanzhou 730046, China) |
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| Abstract: | Objective To investigate the changes of small dense low density lipoprotein cholesterol （ sdLDL-C ） and oxi- dized low density lipoprotein （ ox-LDL ） levels in plasma of donors after long-term intensive plasmapheresis. Methods sdLDL-C and ox-LDL levels in plasma were determined in 100 donors for intensive plasmapheresis and 100 blood donors for a initial plasmapheresis, respectively, and the levels of lipid and protein in plasma were also measured. Results No sig- nificant changes in levels of sdLDL-C, ox-LDL, plasma lipid and protein were observed in intensive plasmapheresis donors. Conclusion In this study the donors for long-term intensive plasmapheresis were safe, and it did not increase cardiovascu- lar risk in relation to atherosclerosis. |
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| Keywords: | Intensive plasmapheresis donor sdLDL-C （small dense low density lipoprotein } ox-LDL （oxidized lowdensity lipoprotein ） Atherosclerosis { As } |
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