Topology of evolving,mutagenized viral populations: quasispecies expansion,compression, and operation of negative selection |
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| Authors: | Samuel Ojosnegros Rubén Agudo Macarena Sierra Carlos Briones Saleta Sierra Claudia González- López Esteban Domingo Juan Cristina |
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| Institution: | 1.Centro de Biología Molecular "Severo Ochoa",UAM-CSIC. Campus de Cantoblanco,Madrid,Spain;2.Laboratorio de Evolución Molecular, Centro de Astrobiología (CSIC/INTA),Instituto Nacional de Técnica Aeroespacial, Ctra de Torrejón a Ajalvir,Torrejón de Ardoz, Madrid,Spain;3.Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd),Spain;4.Institute of Virology,University of Cologne,Cologne,Germany;5.MRC Laboratory for Molecular Cell Biology & Cell Biology Unit,University College London,London,UK;6.Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias,Universidad de la República,Montevideo,Uruguay |
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| Abstract: | Background The molecular events and evolutionary forces underlying lethal mutagenesis of virus (or virus extinction through an excess
of mutations) are not well understood. Here we apply for the first time phylogenetic methods and Partition Analysis of Quasispecies
(PAQ) to monitor genetic distances and intra-population structures of mutant spectra of foot-and-mouth disease virus (FMDV)
quasispecies subjected to mutagenesis by base and nucleoside analogues. |
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