Targeting of proteins to the Golgi apparatus |
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Authors: | Paul A Gleeson Rohan D Teasdale Jo Burke |
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Institution: | (1) Department of Pathology and Immunology, Monash University Medical School, Alfred Hospital, 3181 Melbourne, Victoria, Australia;(2) Department of Pathology and Immunology, Monash University Medical School, Commercial Road, 3181 Prahran, Victoria, Australia;(3) McGill Cancer Centre, McGill University, H3G 1Y6 Montreal, Canada |
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Abstract: | The Golgi apparatus maintains a highly organized structure in spite of the intense membrane traffic which flows into and out of this organelle. Resident Golgi proteins must have localization signals to ensure that they are targeted to the correct Golgi compartment and not swept further along the secretory pathway. There are a number of distinct groups of Golgi membrane proteins, including glycosyltransferases, recyclingtrans-Golgi network proteins, peripheral membrane proteins, receptors and viral glycoproteins. Recent studies indicate that there are a number of different Golgi localization signals and mechanisms for retaining proteins to the Golgi apparatus. This review focuses on the current knowledge in this field. |
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Keywords: | Golgi apparatus glycosyltransferase Golgi retention protein sorting trans-Golgi network |
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