A linkage group with FRA16B (the fragile site at 16q22.1)期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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A linkage group with FRA16B (the fragile site at 16q22.1)

Authors:	J C Mulley V J Hyland A Fratini L J Bates A K Gedeon G R Sutherland

Institution:	(1) Cytogenetics Unit, Department of Histopathology, Adelaide Children's Hospital, 5006 North Adelaide, S.A., Australia

Abstract:	Summary Polymorphic DNA markers located in bands 16q13, 16q21 and 16q22 were examined for recombination with FRA16B, the fragile site at 16q22.100. A tight linkage cluster D16S10-FRA16B-D16S4-HP was established. There were no recombinants ${\text{(}}\hat \theta = {\text{0}}{\text{.0, }}{\mathbf{\hat z}}{\text{ = 8}}{\text{.3)}}$ between D16S10 and D16S4, which flank FRA16B. The markers D16S10 and D16S4 are in close proximity on the genetic map and delineate a small chromosomal segment, which contains the distamycin A-inducible fragile site.

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