Solid-phase synthesis of acridine-based threading intercalator peptides |
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Authors: | Carlson C B Beal P A |
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Affiliation: | Department of Chemistry, University of Utah, Salt Lake City 81112, USA. |
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Abstract: | The preparation of a novel acridine-based amino acid is reported. This N-Alloc-protected monomer can be coupled and deprotected under solid-phase peptide synthesis procedures to create acridine peptide conjugates as potential threading intercalators. A peptide containing this novel amino acid undergoes spectral changes in the presence of duplex DNA and RNA consistent with intercalative binding. |
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