Ultrasonication of insulin-loaded microgel particles produced by internal gelation: Impact on particle's size and insulin bioactivity |
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| Authors: | Ana C. Santos Joana Cunha F. Veiga A. Cordeiro-da-Silva Antonio J. Ribeiro |
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| Affiliation: | 1. Centro de Estudos Farmacêuticos, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal;2. IBMC – Instituto de Biologia Molecular e Celular, University of Porto, 4150-180 Porto, Portugal;3. Institute for the Biomedical Sciences Abel Salazar and Faculty of Medicine, University of Porto, 4050-343 Porto, Portugal;4. Faculty of Pharmacy, University of Porto, 4050-343 Porto, Portugal |
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| Abstract: | Alginate-dextran sulfate (ADS) microgel has been used to protect insulin from gastrointestinal attack and as a carrier to promote insulin permeation through intestinal epithelium. The throughput of ADS submicron particles generation by emulsification/internal gelation is limited by its wide size distribution. |
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| Keywords: | ADS, alginate/dextran sulfate NPs, nanoparticles LD, laser diffractometry CD, circular dichroism DMEM, Dulbecco's modified eagle medium FBS, fetal bovine serum Cryo-SEM, cryo-scanning electron microscopy ANOVA, one way analysis of variance LOD, limit of detection DLS, dynamic light scattering ELS, electrophoretic light scattering PI, polydispersity index w/o, water/oil |
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