Xyloglucan-based diblock co-oligomer: Synthesis,self-assembly and steric stabilization of proteins |
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Authors: | Cony Gauche,Valdir Soldi,Sé bastien Fort,Redouane Borsali,Sami Halila |
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Affiliation: | 1. Centre de Recherches sur les Macromolécules Végétales (CERMAV-CNRS), Université Joseph Fourier (UJF), Institut de Chimie Moléculaire de Grenoble (ICMG-FR 2607 CNRS), PolyNat Carnot Institute, Arcane LabEx, BP 53, F-38041 Grenoble Cedex 9, France;2. Department of Chemistry, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, Brazil |
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Abstract: | We propose a novel plant-based amphiphilic diblock co-oligomers (BCO) surfactant containing only carbohydrate segments and examine its potential as a biosourced stabilizer. The synthesis of an amphiphilic xyloglucan-based BCO, composed of a hydrophilic xyloglucan oligosaccharide (XGO) block “clicked” to a hydrophobic peracetylated XGO is described. Dynamic light scattering experiments correlated with transmission electron microscopy observations showed that this new class of amphiphilic BCO self-assembles in water to form spherical micelles with a hydrodynamic diameter of 22 nm. Preliminary studies indicate that the XGO-based BCO sterically stabilizes gliadin and zein nanoparticle suspensions. The stabilization results were compared to those using pluronic F-68, a commercial surfactant. For gliadin nanoparticles, both surfactants result in essentially the same morphology and polydispersity. However, for the zein nanoparticles, the XGO-based BCO stabilizer gave lower polydispersity. |
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Keywords: | Xyloglucan oligosaccharides Click reaction Amphiphilic block co-oligomer Self-assembly Micelles Protein stabilization |
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