Synthesis and antibacterial activity of new N-linked 5-triazolylmethyl oxazolidinones |
| |
Authors: | Phillips Oludotun A Udo Edet E Ali Ahmed A M Samuel Santhosh M |
| |
Affiliation: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait. dphillips@hsc.edu.kw |
| |
Abstract: | A new series of N-linked 5-triazolylmethyl oxazolidinones with varying substitution at the piperazine nitrogen 4-position were synthesized and tested against a panel of Gram-positive and Gram-negative bacteria including clinical isolates. Most of the compounds showed excellent antibacterial activity against susceptible and resistant Gram-positive organisms. One of the compounds showed enhanced antibacterial activity against Moraxella catarrhalis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|