Semisynthetic preparation of choline and ethanolamine plasmalogens |
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Authors: | Albin Hermetter Fritz Paltauf |
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Institution: | Institut für Biochemie und Lebensmittelchemie, Technische Universität Graz, Schlögelgasse 9, A-8010 Graz Austria |
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Abstract: | Choline and ethanolamine plasmalogens containing defined acyl chains are prepared by deacylation and reacylation of beef heart plasmalogens. During the reactions, the amino group of ethanolamine plasmalogens is protected by the trityl group. Deacylation is achieved by mild alkaline hydrolysis, and the lysoplasmalogens are reacylated with oleoylimidazolide in the presence of the methylsulfinylmethide anion. The protective group is removed from N-trityl ethanolamine plasmalogen by treatment with silicic acid in hexane. The choline and ethanolamine plasmalogens prepared by the procedures described are free of geometric, positional and steric isomers. |
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Keywords: | alkenylacylglycerophospholipids ether lipids reacylation ethanolamine plasmalogens |
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