Comparative study on the properties of saturated phosphatidylethanolamine and phosphatidylcholine bilayers: Barrier characteristics and susceptibility to phospholipase A2 degradation |
| |
Authors: | P.C. Noordam A. Killian R.F.M. Oude Elferink J. de Gier |
| |
Affiliation: | Department of Biochemistry, State University of Utrecht, Transitorium 3, Padualaan 8, 3584 CH Utrecht The Netherlands |
| |
Abstract: | Comparative studies on bilayer systems of saturated phosphatidylcholines and phosphatidylethanolamines revealed a maximum in ionic permeability in phosphatidylcholine bilayers at the temperature of the gel to liquid-crystalline phase transition but such an increase in permeability was not detectable in bilayers of phosphatidylethanolamine. Furthermore, it was found that at the phase transition temperature the phosphatidylcholine bilayers are subject to rapid hydrolysis by pancreatic phospholipase A2 whereas phosphatidylethanolamine bilayers are not. These differences are discussed in view of detailed information on the molecular organization in the gel and liquid crystalline phases of the two phospholipid classes. |
| |
Keywords: | phosphatidylcholine phosphatidylethanolamine phase transition bilayer permeability |
本文献已被 ScienceDirect 等数据库收录! |