Nucleotide and nucleoside involvement in immunomodulation in experimental Chagas disease |
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| Authors: | Guilherme M. do Carmo Mariângela F. de Sá Matheus D. Baldissera Thirssa H. Grando Ricardo E. Mendes Valesca V. Cardoso Emerson A. Casali Cesar Eduardo J. Moritz Silvia G. Monteiro Aleksandro S. Da Silva |
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| Affiliation: | 1.Shanghai Key Laboratory of Diabetes, Department of Endocrinology & Metabolism, Shanghai Diabetes Institute,Shanghai Jiaotong University Affiliated Sixth People’s Hospital,Shanghai,China;2.Department of Endocrinology,The First Affiliated Hospital of Bengbu Medical College,Bengbu,China;3.Department of Nephrology, Shanghai Diabetes Institute,Shanghai Jiaotong University Affiliated Sixth People’s Hospital,Shanghai,China;4.Division of Endocrinology, Metabolism, and Molecular Medicine,Charles R. Drew University of Medicine and Sciences, University of California Los Angeles (UCLA) School of Medicine,Los Angeles,USA |
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| Abstract: | Whether the Arg913Gln variation (rs11643718, G/A) of SLC12A3 contributes to diabetic nephropathy (DN) remains controversial. We undertook a case–control study to evaluate the association of the SLC12A3-Arg913Gln variation with the risk of end-stage renal disease (ESRD) in Chinese type 2 diabetes mellitus (T2DM) patients undergoing hemodialysis, and analyzed the genotype–phenotype interaction. Unrelated Chinese T2DM patients (n = 372) with diabetic retinopathy were classified into the non-DN (control) group (n = 151; duration of T2DM >15 years, no signs of renal involvement) and the DN–ESRD group (n = 221; ESRD due to T2DM, receiving hemodialysis). Polymerase chain reaction-direct sequencing was used to genotype the SLC12A3-Arg913Gln variation for all participants. The frequency of the GA+AA genotype in the DN–ESRD group was significantly higher than that of the non-DN group (23.1 vs. 9.9%; adjusted OR 2.2 (95% CI 1.3–4.5), P = 0.019). In the non-DN group, GA+AA carriers had a significantly higher urinary albumin excretion rate (UAER) and diastolic blood pressure compared with GG carriers (both P < 0.05). The SLC12A3-Arg913Gln variation may be associated with increased blood pressure and UAER and, therefore, could be used to predict the development and progression of DN–ESRD in Chinese T2DM patients undergoing hemodialysis. |
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