Synergistic effect of imp/ostA and msbA in hydrophobic drug resistance of Helicobacter pylori |
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Authors: | Hung-Chuan Chiu Tzu-Lung Lin Jyh-Chin Yang Jin-Town Wang |
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Affiliation: | (1) Department of Microbiology, National Taiwan University College of Medicine;, 10051 Taipei City, Taiwan, Republic of China;(2) Department of Internal Medicine, National Taiwan University Hospital, Taipei City, 10002, Taiwan, Republic of China |
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Abstract: | Background Contamination of endoscopy equipment by Helicobacter pylori (H. pylori) frequently occurs after endoscopic examination of H. pylori-infected patients. In the hospital, manual pre-cleaning and soaking in glutaraldehyde is an important process to disinfect endoscopes. However, this might not be sufficient to remove H. pylori completely, and some glutaraldehyde-resistant bacteria might survive and be passed to the next patient undergoing endoscopic examination through unidentified mechanisms. We identified an Imp/OstA protein associated with glutaraldehyde resistance in a clinical strain, NTUH-C1, from our previous study. To better understand and manage the problem of glutaraldehyde resistance, we further investigated its mechanism. |
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