Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents |
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| Authors: | Zhao Gaiying Miller Marvin J Franzblau Scott Wan Baojie Möllmann Ute |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA. |
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| Abstract: | The syntheses and anti-tuberculosis activity of quinolone-cephalosporin conjugates (1 and 2) are described. Both showed broad-spectrum antibacterial activity and significant anti-TB activity. The carbamate-linked quinolone-cephem 2 showed better antimycobacterial activity, including anti-TB activity, than the direct amine-linked quinolone-cephem 1, while quinolone-cephem 1 was slightly more effective against some Gram-negative bacterial strains. |
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