Treatment options in emerging mold infections |
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Authors: | Patricia Muñoz Jesús Guinea Emilio Bouza |
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Institution: | 1. Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Mara?ón, Calle del Doctor Esquerdo, 46, 28007, Madrid, Spain
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Abstract: | Although Zygomycetes, Fusarium spp, and Scedosporium spp are far less frequent causes of invasive fungal disease than Aspergillus and Candida, they are emerging. These types of infections in severely immunocompromised patients have a common feature: a poor clinical
response to antifungal therapy. Infection is usually airborne, although local infections in cases of skin trauma are also
possible. These fungi are resistant to some common antifungal agents; therefore, surgical debridement of the necrotic tissue,
when possible, should be combined with specific systemic antifungal treatment in immunocompromised patients. In the absence
of randomized clinical trials, most experience in the treatment of these infections is with amphotericin B. Experience with
new antifungal agents is still limited, and recovery from neutropenia remains the main predictor of a favorable outcome. |
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