Presence of transplantable T-lymphoid cells in C57BL/6 mice infected with murine AIDS virus. |
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| Authors: | Y Kubo Y Nakagawa K Kakimi H Matsui M Iwashiro K Kuribayashi T Masuda H Hiai T Hirama S Yanagawa et al. |
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| Affiliation: | Department of Viral Oncology, Faculty of Medicine, Kyoto University, Japan. |
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| Abstract: | The Duplan strain of murine leukemia virus induces murine AIDS in C57BL/6 mice. When spleen cells from C57BL/6 mice infected with the virus were transplanted into nude mice, subcutaneous solid tumors at the transplanted sites were formed and splenomegaly and lymphadenopathy were induced. These transplantable cells were Thy-1- CD4+ alpha-beta T-cell receptor-positive T cells and integrated with the pathogenic defective viral genome. These results indicate that neoplastic cells of T-cell lineage were induced by infecting C57BL/6 mice with murine AIDS virus. |
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