Complement component C1q is sensitive to acute vitamin C defficiency in guinea pigs |
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Authors: | CJ Bates CI Levene RG Oldroyd PJ Lachmann |
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Institution: | 1. M.R.C. Dunn Nutrition Unit, Milton Road, Cambridge, U.K.;2. M.R.C. Connective Tissue Team, Dept. of Pathology, University of Cambridge, Tennis Court Road, Cambridge, U.K.;3. M.R.C. Research Group in Mechanisms in Tour Immunity, The Medical School, Hills Road, Cambridge, U.K. |
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Abstract: | In acutely scorbutic guinea pigs, where interstitial collagen synthesis is markedly impaired, there was no significant reduction in total complement component C1 activity measured by a functional assay, and no significant reduction in the ratio of protein-bound hydroxyproline to protein-bound proline or to total serum protein, in comparison with pair-fed controls. There was a moderate increase in non-protein-bound hydroxyproline in the serum of the deficient animals.These result suggest that component C1q is largely resistant to the effects of severe acute scurvy, adn that some hydroxyproline-containing proteins may respond differently others, during vitamin C deficiency. |
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