Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system |
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Authors: | Hui Xie Jeffrey W Smith |
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Institution: | (1) Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, 92037 La Jolla, CA, USA |
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Abstract: | Particle size is a key feature in determining performance of nanoparticles as drug carriers because it influences circulating
half-life, cellular uptake and biodistribution. Because the size of particles has such a major impact on their performance,
the uniformity of the particle population is also a significant factor. Particles comprised of the polymer poly(lactic-co-glycolic
acid) (PLGA) are widely studied as therapeutic delivery vehicles because they are biodegradable and biocompatible. In fact,
microparticles comprised of PLGA are already approved for drug delivery. Unfortunately, PLGA nanoparticles prepared by conventional
methods usually lack uniformity. We developed a novel Fluidic NanoPrecipitation System (FNPS) to fabricate highly uniform
PLGA particles. Several parameters can be fine-tuned to generate particles of various sizes. |
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