Gene expression studies of developing bovine longissimusmuscle from two different beef cattle breeds |
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| Authors: | Sigrid A Lehnert Antonio Reverter Keren A Byrne Yonghong Wang Greg S Nattrass Nicholas J Hudson Paul L Greenwood |
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| Affiliation: | (1) Cooperative Research Centre for Cattle and Beef Quality, Armidale, Australia;(2) CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia, 4067, Australia;(3) South Australian Research & Development Institute (SARDI), Livestock Systems, Roseworthy, 5371, Australia;(4) School of Integrative Biology, University of Queensland, St Lucia, 4072, Australia;(5) Beef Industry Centre of Excellence, NSW Department of Primary Industries, JSF Barker Building, University of New England, Armidale, 2351, Australia |
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| Abstract: | Background The muscle fiber number and fiber composition of muscle is largely determined during prenatal development. In order to discover genes that are involved in determining adult muscle phenotypes, we studied the gene expression profile of developing fetal bovine longissimus muscle from animals with two different genetic backgrounds using a bovine cDNA microarray. Fetal longissimus muscle was sampled at 4 stages of myogenesis and muscle maturation: primary myogenesis (d 60), secondary myogenesis (d 135), as well as beginning (d 195) and final stages (birth) of functional differentiation of muscle fibers. All fetuses and newborns (total n = 24) were from Hereford dams and crossed with either Wagyu (high intramuscular fat) or Piedmontese (GDF8 mutant) sires, genotypes that vary markedly in muscle and compositional characteristics later in postnatal life. |
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