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The synthesis and biological activity of Ala3,14-somatostatin |
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| Authors: | D Sarantakis W A McKinley N H Grant |
| Affiliation: | Research Division, Wyeth Laboratories, Inc. Philadelphia, Pennsylvania 19101 USA |
| Abstract: | The tetradecapeptide H-Ala-Gly-Ala-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Ala-OH (Ala3, 14-somatostatin) an analog of the somatotropin release inhibiting factor (somatostatin SRIF) was synthesized by solid phase peptide methods. It shows somatotropin release inhibiting activity at 5 μg/ml concentration. |
| Keywords: | BOC tert-butyloxycarbonyl 2-Cl-Cbz 2-chlorobenzyloxycarbonyl Bzl benzyl DCC dicyclohexycarbodiimide DMF dimethyl formamide |
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