| 黑胸大蠊浓核病毒分类的相关研究 |
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| 引用本文： | 李莉,郭海涛,张珈敏,胡远扬.黑胸大蠊浓核病毒分类的相关研究[J].Virologica Sinica,2003,18(5):486-491. |
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| 作者姓名： | 李莉 郭海涛 张珈敏 胡远扬 |
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| 作者单位： | 武汉大学病毒研究所，武汉大学病毒研究所，武汉大学病毒研究所，武汉大学病毒研究所 湖北武汉 430072，湖北武汉 430072，湖北武汉 430072，湖北武汉 430072 |
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| 基金项目： | 国家自然科学基金(39470032) |
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| 摘 要： | 黑胸大蠊浓核病毒(pfDNV)是在我国首先发现并正式分类鉴定的蟑螂浓核病毒。该病毒属细小病毒科(Parvoviridae)，浓核病毒亚科(Densovirinae)。但对该病毒的归属问题却一直没有确定，本文对此予以探讨。pfDNV的最新研究进展包括两个方面：全基因组核苷酸序列的测定，以及利用低温电镜技术和像重构方法对该病毒的三维重构(分辨率23A)。在此基础上，本文将pfDNV与其它病毒在基因组结构和三维结构方面进行了全面的对比分析，其结果并不支持目前对pfDNV的分类，因此建议对该病毒重新进行分类。
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| 关 键 词： | 黑胸大蠊浓核病毒 分类 基因组结构 三维重构 蟑螂浓核病毒 |
Studies on Reclassifying of Periplaneta fuliginosa Densovirus |
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| LI Li,GUO Hai-tao,ZHANG Jia-min,HU Yuan-yang.Studies on Reclassifying of Periplaneta fuliginosa Densovirus[J].中国病毒学(英文版),2003,18(5):486-491. |
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| Authors: | LI Li GUO Hai-tao ZHANG Jia-min HU Yuan-yang |
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| Institution: | LI Li,GUO Hai-tao,ZHANG Jia-min,HU Yuan-yang~ |
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| Abstract: | Periplaneta fuliginosa densovirus (pfDNV) was found in China at the first time, has been classified into the subfamily Densovirinae in Parvoviridae. However, which genus that it belongs to has not yet been determined and is the focus of the present work. Recent advances in the investigation of pfDNV include two aspects: the sequence of the complete genome of the virus and the three- dimensional reconstruction of the virus at the resolution of 23 using the techniques of cryo-electron microscopy and image reconstruction. With these data, pfDNV is extensively compared in the present work with other Parvoviruses with respect to the characteristics of the genome organisations and three-dimensional structures. Our results do not support the current classification of pfDNV. Therefore, a suggestion is made to reclassify pfDNV. |
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| Keywords: | Periplaneta fuliginosa densovirus (pfDNV) Classify Genome organizations 3D structures |
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