Synthesis of novel 4'-modified neplanocin A analogues and their inhibitory activity against S-adenosyl-L-l-homocysteine hydrolase |
| |
| Authors: | Kumamoto Hiroki Deguchi Kazuki Takahashi Nonoko Tanaka Hiromichi Kitade Yukio |
| |
| Affiliation: | School of Pharmaceutical Sciences, Showa University, Tokyo, Japan. kumamoto@pharm.showa-u.ac.jp |
| |
| Abstract: | A new approach was developed for the synthesis of 4'-modified neplanocin A analogues, as potential inhibitors against S-adenosyl-L-homocysteine hydrolase. The vinylstannane 13, a key intermediate in the present approach, was prepared by radical-mediated sulfur-extrusive stannylation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
