Synthesis,DNA/protein binding and in vitro cytotoxic studies of new palladium metallothiosemicarbazones |
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| Authors: | R Prabhakaran P Kalaivani P Poornima F Dallemer R Huang V Vijaya Padma K Natarajan |
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| Institution: | 1. Department of Chemistry, Bharathiar University, Coimbatore 641 046, India;2. Department of Biotechnology, Bharathiar University, Coimbatore 641 046, India;3. Laboratoire Chimie Provence-CNRS UMR6264, Université of Aix-Marseille I, II and III—CNRS, Campus Scientifique de Saint-Jérôme, Avenue Escadrille Normandie-Niemen, F-13397 Marseille Cedex 20, France;4. Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA |
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| Abstract: | A series of four new thiosemicarbazone complexes of palladium have been synthesized, characterized and evaluated for their DNA/protein binding with CT-DNA and BSA, respectively. The new complexes bound to CT-DNA by intercalation mode and in protein binding studies, the complexes bound to BSA binding mechanism was found as static quenching. Among them the complex 4 had a strong binding affinity with BSA. In addition, in vitro cytotoxic studies were carried out on lung cancer (A549) and liver cancer (HepG2) cell lines and found that the complexes exhibited better activity than their parent thiosemicarbazone analogues. The complex 3 exhibited better activity than other complexes and this fact supported by the increased accumulation of the complexes in to the cancer cells which are evident from inter cellular uptake studies. |
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| Keywords: | Thiosemicarbazones Palladium(II) complexes CT-DNA binding BSA binding Cytotoxicity Cellular uptake |
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