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Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity |
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| Authors: | Tiziana Bozzini Giorgia Botta Michela Delfino Silvano Onofri Raffaele Saladino Donatella Amatore Rossella Sgarbanti Lucia Nencioni Anna Teresa Palamara |
| Institution: | 1. Department of Ecology and Biology, University of Tuscia, Via S. Camillo de Lellis, 01100 Viterbo, Italy;2. Department of Public Health and Infectious Diseases, Institute Pasteur, Cenci-Bolognetti Foundation, ‘Sapienza’ University of Rome, Rome, Italy;3. Ceinge, Naples, Italy;4. San Raffaele Pisana Scientific Institute for Research, Hospitalization and Health Care, Rome, Italy;5. Università Telematica San Raffaele, Rome, Italy |
| Abstract: | Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties. |
| Keywords: | Catechols Biocatalysis Immobilized tyrosinase Antiviral Influenza A virus |
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