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The Crystal Structures of the Eukaryotic Chaperonin CCT Reveal Its Functional Partitioning
Authors:Nir Kalisman  Gunnar F Schröder  Michael Levitt
Institution:1. Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA;2. Institute of Complex Systems (ICS-6), Forschungszentrum Jülich, 52425 Jülich, Germany;3. Physics Department, Heinrich-Heine University, 40225 Düsseldorf, Germany
Abstract:
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  • Highlights? CCT subunit types can be identified in crystallographic data, even at low resolutions ? Actin and tubulin both bind around CCT6 ? ATP hydrolysis and substrate binding are partitioned in the CCT particle
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