1. Department of Neurobiology, Northwestern University, Evanston, IL 60208-3500, USA;2. Institute for Computational Molecular Science, Temple University, Philadelphia, PA 19122-6078, USA;3. Department of Chemistry, Temple University, Philadelphia, PA 19122-6078, USA;4. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158-9001, USA;5. Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208-3500, USA;6. Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208-3500, USA