首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Human IL-34 and CSF-1 Establish Structurally Similar Extracellular Assemblies with Their Common Hematopoietic Receptor
Authors:Jan Felix  Jonathan Elegheert  Irina Gutsche  Alexander V Shkumatov  Yurong Wen  Nathalie Bracke  Erwin Pannecoucke  Isabel Vandenberghe  Bart Devreese  Dmitri I Svergun  Ewald Pauwels  Bjorn Vergauwen  Savvas N Savvides
Institution:1. Unit for Structural Biology, Laboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium;2. Unit for Biological Mass Spectrometry and Proteomics, Laboratory for Protein Biochemistry and Biomolecular Engineering (L-ProBE), Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium;3. Unit of Virus Host Cell Interactions, UVHCI, UMI 3265 UJF-EMBL-CNRS, 6 rue Jules Horowitz, BP 181, 38042 Grenoble cedex 9, France;4. Biological Small Angle Scattering Group, EMBL, Notkestraße 85, 22603 Hamburg, Germany;5. Center for Molecular Modeling, Ghent University, Technologiepark 903, 9052 Zwijnaarde, Belgium
Abstract:
><ol class=
  • Download : Download high-res image (402KB)
  • Download : Download full-size image
  • Highlights? Structural insights into the complete extracellular human IL-34:CSF-1R complex ? The C-terminal tail of hIL-34 is flexible and heavily O-linked glycosylated ? Inclusion of N-linked glycans drastically improves fitting of models to SAXS data ? Consensus principles for hCSF-1R activation by its two distinct cytokine ligands
    Keywords:
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号