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Design of a Phosphorylatable PDZ Domain with Peptide-Specific Affinity Changes

Authors:	Colin A Smith Catherine A Shi Matthew K Chroust Thomas E Bliska Mark JS Kelly Matthew P Jacobson Tanja Kortemme

Institution:	6. Williams College, 880 Main Street, Williamstown, MA 01267, USA

Abstract:	Download : Download high-res image (234KB) Download : Download full-size image Highlights? Successful design of phosphorylation sites into a globular protein ? Redesigned PDZ domain phosphorylation is associated with local destabilization ? Phosphorylation switches peptide binding function ? Phosphorylation switches peptide recognition specificity

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