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Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors |
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| Authors: | Tzung-Sheng Lin Ya-Wen Liw Jen-Shin Song Tsung-Chih Hsieh Hsien-Wei Yeh Lih-Ching Hsu Chun-Jung Lin Szu-Huei Wu Pi-Hui Liang |
| Affiliation: | 1. School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan;2. Institute of Biotechnology and Pharmaceutical Research, National Health Research Institute, Miaoli County 35053, Taiwan |
| Abstract: | Novel C-aryl-d-glucofuranosides were synthesized and evaluated for their capacity to inhibit human sodium-dependent glucose co-transporter 2 (hSGLT2) and hSGLT1. Compound 21q demonstrated the best in vitro inhibitory activity against SGLT2 in this series (EC50 = 0.62 μM). |
| Keywords: | Antidiabetics SGLT Glucofuranosides |
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