1. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA;2. Department of Chemistry, University of Washington, Seattle, WA 98195, USA;3. Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, WA 98195, USA;4. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA