New nitric oxide donating 1,2,4-triazole/oxime hybrids: Synthesis,investigation of anti-inflammatory,ulceroginic liability and antiproliferative activities |
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Authors: | Mohamed Abdel-Aziz Gamal El-Din A.A. Abuo-Rahma Eman A.M. Beshr Taha F.S. Ali |
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Affiliation: | Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. |
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Abstract: | A series of novel nitric oxide (NO) donating triazole/oxime hybrids was prepared and evaluated for their anti-inflammatory activity. Most of the tested compounds showed significant anti-inflammatory activity using carrageenan-induced rat paw edema method compared to indomethacin. Calculation of the ulcer indices and histopathological investigation indicated that the prepared NO-donating oximes exhibited less ulcerogenicity compared to their intermediate ketones and indomethacin. The NO-donating oxime 6i revealed significant activity against renal cancer A498 cell lines with 50.52 cell growth inhibition. |
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Keywords: | 1,2,4-Triazole Nitric oxide donors Anti-inflammatory Gastric ulceration Antiproliferative |
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