Leukemia Fusion Target AF9 Is an Intrinsically Disordered Transcriptional Regulator that Recruits Multiple Partners via Coupled Folding and Binding期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Leukemia Fusion Target AF9 Is an Intrinsically Disordered Transcriptional Regulator that Recruits Multiple Partners via Coupled Folding and Binding

Authors:	Benjamin I. Leach,Aravinda Kuntimaddi,Charles R. Schmidt,Tomasz Cierpicki,Stephanie A. Johnson,John H. Bushweller

Affiliation:	1. Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA;2. Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA

Abstract:	Download : Download high-res image (147KB) Download : Download full-size image Highlights? The AF9 AHD is intrinsically disordered ? The AHD recruits AF4, BCoR, Dot1L, and hPC3 by coupled folding and binding ? AF9 binding partners compete for binding to a common site ? Dynamics of the AF4-AF9 complex may facilitate exchange between partners

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