1. Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;2. Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;3. Department of Physiology and Pharmacology, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, Morgantown, WV 26506, USA
Abstract:
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Highlights? E. histolytica expresses a convergently evolved RGS-RhoGEF protein ? EhRGS-RhoGEF possesses a conventional nine-helix RGS domain ? Activated EhRGS-RhoGEF induces S2 cell spreading through Rac1/2 ? EhRGS-RhoGEF modulates amoebic migration and host cell killing
