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Kinetic,Energetic, and Mechanical Differences between Dark-State Rhodopsin and Opsin

Authors:	Shiho Kawamura Moritz Gerstung Alejandro T Colozo Jonne Helenius Akiko Maeda Niko Beerenwinkel Paul S-H Park Daniel J Müller

Institution:	1. Department of Biosystems Science and Engineering, ETH Zürich, 4058 Basel, Switzerland;2. SIB Swiss Institute of Bioinformatics, 4058 Basel, Switzerland;3. Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK;4. Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA

Abstract:	Download : Download high-res image (259KB) Download : Download full-size image Highlights? Mapping the stability of opsin from the rod outer segment of the mouse eye ? Compared to dark-state rhodopsin opsin increases mechanical stability and rigidity ? Compared to dark-state rhodopsin opsin reduces lifetime and free energy ? Compared to dark-state rhodopsin opsin is pliable and adopts alternate conformations

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