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Y-Family Polymerase Conformation Is a Major Determinant of Fidelity and Translesion Specificity

Authors:	Ryan C Wilson Meghan A Jackson Janice D Pata

Institution:	1. Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509, USA;2. Department of Biomedical Sciences, University at Albany, Albany, NY 12201-0509, USA

Abstract:	Download : Download high-res image (246KB) Download : Download full-size image Highlights? Y-family polymerases differ in fidelity and translesion synthesis specificity ? Polymerase fidelity and specificity are controlled by the interdomain linker ? Three amino acids in the interdomain linker are sufficient to determine conformation ? Differences in polymerase conformation determine differences in polymerase activity

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