1. Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA;2. Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA;3. Departments of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA;4. Medicine and Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, USA;5. Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH 43210, USA