Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields |
| |
Authors: | Mangiacasale R Tritarelli A Sciamanna I Cannone M Lavia P Barberis M C Lorenzini R Cundari E |
| |
Affiliation: | CNR Centro di Genetica Evoluzionistica c/o Università La Sapienza, Rome, Italy. |
| |
Abstract: | Human lymphoblastoid cells of normal origin and from genetic instability syndromes, i.e. Fanconi anemia (FA) group C and ataxia telangectasia, were continuously exposed to extremely low frequency magnetic field (ELF-MF). We report that ELF-MF, though not perturbing cell cycle progression, increases the rate of cell death in normal cell lines. In contrast, cell death is not affected in cells from genetic instability syndromes; this reflects a specific failure of the apoptotic response. Reintroduction of complementation group C in FA cells re-established the apoptotic response to ELF-MF. Thus, genes implicated in genetic instability syndromes are relevant in modulating the response of cells to ELF-MF. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|