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In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe
Authors:Barbosa T  Arruda S  Cavada B  Grangeiro T B  de Freitas L A  Barral-Netto M
Affiliation:Centro de Pesquisas Gon?alo Moniz-Fiocruz, 40295-001 Salvador, BA, Brasil.
Abstract:This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects.
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