The effects of prolonged deep freezing on the biomechanical properties of osteochondral allografts |
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Authors: | Benjamin Rozen Tamar Brosh Moshe Salai Amir Herman Israel Dudkiewicz |
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Institution: | (1) Rabin Medical Center, Petah Tikva, Israel;(2) Fine Measurements Laboratory, Tel Aviv University, Israel |
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Abstract: | Musculo-skeletal allografts sterilized and deep frozen are among the most common human tissue to be preserved and utilized
in modern medicine. The effects of a long deep freezing period on cortical bone has already been evaluated and found to be
insignificant. However, there are no reports about the influences of a protracted deep freezing period on osteochondral allografts.
One hundred osteochondral cylinders were taken from a fresh specimen and humeral heads of 1 year, 2 years, 3 years and 4 year
old bones. Twenty chips from each period, with a minimum of 3 chips per humeral head. Each was mechanically tested by 3 point
compression. The fresh osteochondral allografts were significantly mechanically better than the deep frozen osteochondral
allografts. There was no statistical significant time dependent difference between the deep frozen groups in relation to the
freezing period. Therefore, we conclude that, from the mechanical point of view deep freezing of osteochondral allografts
over a period of 4 years, is safe without further deterioration of the biomechanical properties of the osteochondral allografts. |
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Keywords: | Prolonged deep freezing Biomechanical properties Osteochondral allografts |
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