Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death |
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Authors: | Heinrich J Huber Maike A Laussmann Jochen HM Prehn Markus Rehm |
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Institution: | (1) Sytems Biology Group, Department of Physiology & Medical Physics, Royal College of Surgeons in Ireland, 2 Dublin, Ireland;(2) Siemens Ireland, Leeson Close, 2 Dublin, Ireland |
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Abstract: | Background Apoptosis is an essential cell death process throughout the entire life span of all metazoans and its deregulation in humans
has been implicated in many proliferative and degenerative diseases. Mitochondrial outer membrane permeabilisation (MOMP)
and activation of effector caspases are key processes during apoptosis signalling. MOMP can be subject to spatial coordination
in human cancer cells, resulting in intracellular waves of cytochrome-c release. To investigate the consequences of these
spatial anisotropies in mitochondrial permeabilisation on subsequent effector caspase activation, we devised a mathematical
reaction-diffusion model building on a set of partial differential equations. |
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