Anti-Candida property of a lignan glycoside derived from Styrax japonica S. et Z. via membrane-active mechanisms |
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Authors: | Cana Park Eun-Rhan Woo Dong Gun Lee |
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Institution: | 2. School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, 702-701, Korea 1. College of Pharmacy, Chosun University, Gwangju, 501-759, Korea
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Abstract: | Styraxjaponoside C was investigated with respect to its antifungal activity and mechanisms of action. Devoid of hemolytic
activity, Styraxjaponoside C demonstrated an antifungal effect against the human pathogenic yeast Candida albicans in an energy-independent manner. To characterize the mechanisms of the antifungal activity of Styraxjaponoside C, fluorescence
analysis with membrane probe 1,6-diphenyl-1,3,5-hexatriene, and flow cytometric analysis on C. albicans were conducted. The results showed that Styraxjaponosdie C induced cytoplasmic membrane perturbation. The current study suggested
that Styraxjaponoside C was active against C. albicans with membrane-active mechanisms. |
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