Changes in creatine transporter function during cardiac maturation in the rat |
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Authors: | Alexandra Fischer Michiel ten Hove Liam Sebag-Montefiore Helga Wagner Kieran Clarke Hugh Watkins Craig A Lygate Stefan Neubauer |
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Institution: | 1.Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics,University of Oxford,Oxford,UK;2.Department of Cardiology,Medizinische Universit?tsklinik Würzburg,Würzburg,Germany;3.Department of Physiology,University of Oxford,Oxford,UK |
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Abstract: | Background It is well established that the immature myocardium preferentially utilises non-oxidative energy-generating pathways. It exhibits
low energy-transfer capacity via the creatine kinase (CK) shuttle, reflected in phosphocreatine (PCr), total creatine and
CK levels that are much lower than those of adult myocardium. The mechanisms leading to gradually increasing energy transfer
capacity during maturation are poorly understood. Creatine is not synthesised in the heart, but taken up exclusively by the
action of the creatine transporter protein (CrT). To determine whether this transporter is ontogenically regulated, the present
study serially examined CrT gene expression pattern, together with creatine uptake kinetics and resulting myocardial creatine
levels, in rats over the first 80 days of age. |
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