Changes in cerebellar iron metabolism and their prevention by allopurinol in oxidative stress related to acute ethanol administration in rats |
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| Authors: | H Rouach P Houzé M Park R Nordmann |
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| Institution: | Département de Recherches Biomédicales sur l'Alcoolisme, Université René-Descartes, Paris. |
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| Abstract: | An acute ethanol load results in an increased total nonheme iron and cytosolic low molecular weight iron content in rat cerebellum. At the same time the cerebellar susceptibility to lipid peroxidation is enhanced whereas the alpha-tocopherol and ascorbate content is decreased. These changes argue for a cerebellar ethanol-induced oxidative stress, which is prevented by prior allopurinol administration. |
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