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Straightforward syntheses of furanomycin derivatives and their biological evaluation |
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| Authors: | Kazmaier Uli Pähler Saskia Endermann Rainer Häbich Dieter Kroll Hein-Peter Riedl Bernd |
| Institution: | a Institut für Organische Chemie, Universität des Saarlandes, Im Stadtwald, Geb. 23.2, 66123 Saarbrücken, Germany b Bayer AG, Pharma Research, 42096 Wuppertal, Germany |
| Abstract: | Several types of furanomycin analogues were synthesized and investigated with respect to their antibacterial activity. Two different synthetic pathways were developed, based on aldol reactions/ring closing metathesis and an ester enolate Claisen rearrangement. Only the natural product and its desmethyl derivative showed antibacterial activity, pointing towards a narrow structure–activity relationship. |
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