Sorbitol-mediated stabilization of human IgG against thermal inactivation |
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| Authors: | Federico Cioci Roberto Lavecchia |
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| Institution: | (1) Department of Chemical Engineering, University  La Sapienza , Via Eudossiana Roma, Italy |
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| Abstract: | Sorbitol at 30% (w/w) stabilized human IgG to thermal denaturation from 60 to 85°C, increasing the protein's half life from 25 to 266 min at 70°C. A kinetic model based on the Lumry-Eyring inactivation scheme was developed and used to estimate the apparent rate constant and activation energy. © Rapid Science. 1998 |
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| Keywords: | Immunoglobulins sorbitol protein denaturation stabilization |
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