Localization of the human fibronectin (FN) gene on chromosome 8 by a specific enzyme immunoassay |
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| Authors: | Stephen I. Rennard Robert L. Church David H. Rohrbach Dolores E. Shupp Shigeto Abe A. Tyl Hewitt J. Clifford Murray George R. Martin |
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| Affiliation: | (1) Laboratory of Developmental Biology and Anomalies, National Institute of Dental Research, National Institutes of Health, 20205 Bethesda, Maryland;(2) School of Medicine and Eye and Ear Hospital, University of Pittsburgh, 15213 Pittsburgh, Pennsylvania |
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| Abstract: | The fibronectin produced by clonal murine-human hybrid cell lines containing various complements of human chromosomes was measured. Human and murine fibronectins were assayed by specific immunoassay, and the production of human fibronectin was correlated with karyology and isozyme markers for specific human chromosomes. The data show a 100% concordance between the expression of human fibronectin and glutathione reductase, a marker for human chromosome 8, indicating that chromosome 8 codes for the fibronectin polypeptide. |
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| Keywords: | fibronecting gene mapping ELISA murine-human hybrids |
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